Tg(LCR-HBA1,LCR-HBB*)1Tow
Transgene Detail

Summary

• Symbol: Tg(LCR-HBA1,LCR-HBB*)1Tow
• Name: transgene insertion 1, Timothy Townes
• MGI ID: MGI:5484766
• Synonyms: Tg(LCR-HBA1,-HBB*)1Tow
• Transgene: Tg(LCR-HBA1,LCR-HBB*)1Tow Location: unknown
• Alliance: Tg(LCR-HBA1,LCR-HBB*)1Tow page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LCR-HBA1,LCR-HBB*)1Tow expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBA1 (3039)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

• Mutation details: Two transgenes were designed to each be controlled independently by five upstream sites (HS I-V) of the human beta-globin locus control regions (LCR). The HS I-V betaS transgene expresses a glutamic acid to valine mutation of the human hemoglobin beta chain complex (HBB) that has been linked to sickle cell disease. The HS I-V alpha transgene expresses a human alpha1 globin (HBA1) gene. Line 1 was generated. (J:127701)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:127701 Ryan TM, et al., Human sickle hemoglobin in transgenic mice. Science. 1990 Feb 2;247(4942):566-8
• All: 1 reference(s)