Grb2^tm3.1Paw
Targeted Allele Detail

Summary

• Symbol: Grb2^tm3.1Paw
• Name: growth factor receptor bound protein 2; targeted mutation 3.1, Tony Pawson
• MGI ID: MGI:5484776
• Synonyms: Grb2^flx
• Gene: Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Grb2^tm3.1Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked trapping construct (splice acceptor, IRES and beta-geo cassette) with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the trapping construct and left exon 2 floxed. (J:195444)

Generation of the Grb2^tm3.1Paw allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grb2 Mutation: 43 strains or lines available

References

• Original: J:195444 Bisson N, et al., The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS One. 2012;7(11):e50996
• All: 2 reference(s)