Eps15^tm1Noff
Targeted Allele Detail

Summary

• Symbol: Eps15^tm1Noff
• Name: epidermal growth factor receptor pathway substrate 15; targeted mutation 1, Nina Offenhauser
• MGI ID: MGI:5485036
• Gene: Eps15 Location: Chr4:109137465-109245014 bp, + strand Genetic Position: Chr4, 51.29 cM, cytoband C7
• Alliance: Eps15^tm1Noff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195689
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the spleen. (J:195689)

Generation of the Eps15^tm1Noff allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eps15 Mutation: 66 strains or lines available

References

• Original: J:195689 Pozzi B, et al., The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818
• All: 2 reference(s)