Ptk2^tm3.1Guan
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm3.1Guan
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 3.1, Jun-Lin Guan
• MGI ID: MGI:5485069
• Synonyms: FAK PA
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm3.1Guan page

Suppressed mammary tumor growth in Ptk2^tm3.1Guan/Ptk2^tm3.1Guan Tg(MMTV-PyVT)634Mul/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195658
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 28 was replaced with a floxed neo cassette and a modified exon 28 in which nucleotide substitution results in the amino acid substitution of alanine for proline at positions 878 and 881 (P878A, P881A). Cre-mediated recombination removed the neo cassette. (J:195658)

Generation of the Ptk2^tm3.1Guan allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:195658 Fan H, et al., Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem. 2013 Feb 1;288(5):3322-33
• All: 1 reference(s)