Slc29a4^tm1Jowg
Targeted Allele Detail

Summary

• Symbol: Slc29a4^tm1Jowg
• Name: solute carrier family 29 (nucleoside transporters), member 4; targeted mutation 1, Joanne Wang
• MGI ID: MGI:5485154
• Gene: Slc29a4 Location: Chr5:142678267-142708245 bp, + strand Genetic Position: Chr5, 81.56 cM
• Alliance: Slc29a4^tm1Jowg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195656
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 3 through 7. Cell assay confirmed the product has no transport activity for organic cations and monoamines. (J:195656)

Generation of the Slc29a4^tm1Jowg allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc29a4 Mutation: 35 strains or lines available

References

• Original: J:195656 Duan H, et al., Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J Biol Chem. 2013 Feb 1;288(5):3535-44
• All: 3 reference(s)