Cd28^tm1Ltu
Targeted Allele Detail

Summary

• Symbol: Cd28^tm1Ltu
• Name: CD28 antigen; targeted mutation 1, Laurence A Turka
• MGI ID: MGI:5485211
• Synonyms: Cd28^fl
• Gene: Cd28 Location: Chr1:60785547-60812521 bp, + strand Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
• Alliance: Cd28^tm1Ltu page

Skin inflammation and enlarged lymph nodes and spleen in Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194503
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:194503)

Generation of the Cd28^tm1Ltu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd28 Mutation: 52 strains or lines available

Notes

ES cell line = PB6 (C57BL/6)

References

• Original: J:194503 Zhang R, et al., An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest. 2013 Feb;123(2):580-93
• All: 7 reference(s)