Prkcz^tm1.1Rlh
Targeted Allele Detail

Summary

• Symbol: Prkcz^tm1.1Rlh
• Name: protein kinase C, zeta; targeted mutation 1.1, Richard L Huganir
• MGI ID: MGI:5485243
• Synonyms: PKCzeta^fl, PKCzeta//PKM-zeta^fl
• Gene: Prkcz Location: Chr4:155344586-155445818 bp, - strand Genetic Position: Chr4, 86.17 cM, cytoband E2
• Alliance: Prkcz^tm1.1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194557
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 11 was floxed. Flp-mediated recombination removed an FRT-flanked neo cassette inserted downstream of exon 10 (initially described as exon 11) of the canonical sequence. (J:194557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcz Mutation: 43 strains or lines available

References

• Original: J:194557 Volk LJ, et al., PKM-zeta is not required for hippocampal synaptic plasticity, learning and memory. Nature. 2013 Jan 17;493(7432):420-3
• All: 1 reference(s)