Prkcz^tm1.2Rlh
Targeted Allele Detail

Summary

• Symbol: Prkcz^tm1.2Rlh
• Name: protein kinase C, zeta; targeted mutation 1.2, Richard L Huganir
• MGI ID: MGI:5485244
• Gene: Prkcz Location: Chr4:155344586-155445818 bp, - strand Genetic Position: Chr4, 86.17 cM, cytoband E2
• Alliance: Prkcz^tm1.2Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11 was floxed. Cre-mediated recombination removed exon 11 and an FRT-flanked neo cassette inserted downstream of exon 11. Western blot analysis confirmed the absence of PKC-zeta and the isoform protein kinase M-zeta (PKM-zeta) in the brain. Protein expression of other PCK isoforms is normal. (J:194557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcz Mutation: 43 strains or lines available

References

• Original: J:194557 Volk LJ, et al., PKM-zeta is not required for hippocampal synaptic plasticity, learning and memory. Nature. 2013 Jan 17;493(7432):420-3
• All: 2 reference(s)