Tg(Cnp-EGFR)10Nrat
Transgene Detail

Summary

• Symbol: Tg(Cnp-EGFR)10Nrat
• Name: transgene insertion 10, Nancy Ratner
• MGI ID: MGI:5485351
• Synonyms: Cnp-EGFR, CNP-hEGFR
• Transgene: Tg(Cnp-EGFR)10Nrat Location: unknown
• Alliance: Tg(Cnp-EGFR)10Nrat page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cnp-EGFR)10Nrat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: The 2'3'-cyclic nucleotide 3'-phosphodiesterase promoter, specific for Schwann cells in peripheral nerve, drives the expression of human EGFR. Two lines, 10 and 46, were made. (J:95933)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:95933 Ling BC, et al., Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell. 2005 Jan;7(1):65-75
• All: 7 reference(s)