Cldn4^tm1.1Yham
Targeted Allele Detail

Summary

• Symbol: Cldn4^tm1.1Yham
• Name: claudin 4; targeted mutation 1.1, Yoko Hamazaki
• MGI ID: MGI:5485358
• Gene: Cldn4 Location: Chr5:134973977-134975788 bp, - strand Genetic Position: Chr5, 74.9 cM
• Alliance: Cldn4^tm1.1Yham page

Urothelial hyperplasia in Cldn4^tm1.1Yham/Cldn4^tm1.1Yham mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195766
• Parent Cell Line: D3a2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of the coding sequence. An additional loxP site was inserted downstream of the coding sequence. Cre-mediated recombination removed the neo cassette and coding sequence. Western blot analysis confirmed the absence of protein expression in the bladder mucosa. (J:195766)

Establishment of the Cldn4^tm1.1Yham allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn4 Mutation: 10 strains or lines available

References

• Original: J:195766 Fujita H, et al., Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLoS One. 2012;7(12):e52272
• All: 1 reference(s)