Hdac1^tm1.1Shmc
Targeted Allele Detail

Summary

• Symbol: Hdac1^tm1.1Shmc
• Name: histone deacetylase 1; targeted mutation 1.1, Shaun M Cowley
• MGI ID: MGI:5485390
• Synonyms: Hdac1^Lox
• Gene: Hdac1 Location: Chr4:129409897-129436506 bp, - strand Genetic Position: Chr4, 63.26 cM
• Alliance: Hdac1^tm1.1Shmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194769
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:160317, J:194769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac1 Mutation: 38 strains or lines available

References

• Original: J:194769 Dovey OM, et al., Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice. Blood. 2013 Feb 21;121(8):1335-44
• All: 3 reference(s)