Macroh2a1^tm1Mbou
Targeted Allele Detail

Summary

• Symbol: Macroh2a1^tm1Mbou
• Name: macroH2A.1 histone; targeted mutation 1, Mathieu Boulard
• MGI ID: MGI:5485999
• Gene: Macroh2a1 Location: Chr13:56221435-56283439 bp, - strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: Macroh2a1^tm1Mbou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195833
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exon 2. Western blot anlaysis confirmed the absence of protein expression in the brain, liver, testis, spleen, kidney and thymus. (J:195833)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macroh2a1 Mutation: 50 strains or lines available

References

• Original: J:195833 Boulard M, et al., Histone variant macroH2A1 deletion in mice causes female-specific steatosis. Epigenetics Chromatin. 2010;3(1):8
• All: 2 reference(s)