Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch
Transgene Detail

Summary

• Symbol: Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch
• Name: transgene insertion 1, Pao-Tien Chuang
• MGI ID: MGI:5486022
• Synonyms: SPC^rtTA
• Transgene: Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch Location: unknown
• Alliance: Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sftpc (MGI:109517)

• Mutation details: A BAC clone spanning the Sftpc (SPC) and Nudt18 genomic regions of mouse chromosome 14 was modified to insert a reverse tetracycline transactivator sequence at the start ATG of the Sftpc locus. A second round of recombination was performed to insert a cre recombinase sequence under the control of the tetracycline responsive element (tetO) at the start ATG of the Nudt18 gene. Founder information was not available. (J:195738)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sftpc (mouse) Summary of all recombinase alleles driven by Sftpc. Alliance mouse Sftpc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:195738 Lin C, et al., Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012;7(12):e53817
• All: 1 reference(s)