Ano6^tm1Avor
Targeted Allele Detail

Summary

• Symbol: Ano6^tm1Avor
• Name: anoctamin 6; targeted mutation 1, Andrea Vortkamp
• MGI ID: MGI:5486205
• Gene: Ano6 Location: Chr15:95688724-95872632 bp, + strand Genetic Position: Chr15, 50.66 cM
• Alliance: Ano6^tm1Avor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195901
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette replaced exon 1. RT-PCR confirmed the absence of transcript expression in the osteoblasts. (J:195901)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano6 Mutation: 83 strains or lines available

References

• Original: J:195901 Ehlen H, Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013;28(2):246-59
• All: 6 reference(s)