Wwtr1^tm1Hmc
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1Hmc
• Name: WW domain containing transcription regulator 1; targeted mutation 1, Helen McNeill
• MGI ID: MGI:5486299
• Synonyms: Taz^flox
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1Hmc page

Nephrogenesis abnormalities in Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺, Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ and double mutant mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195266
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted in intron 1 and a loxP site and FRT-flanked neo cassette were inserted in intron 2 via homologous recombination. (J:195266)

Generation of the Wwtr1^tm1Hmc allele

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
• All: 44 reference(s)