Rr27^tm2.1Pes
Targeted Allele Detail

Summary

• Symbol: Rr27^tm2.1Pes
• Name: regulatory region 27; targeted mutation 2.1, Piroska E Szabo
• MGI ID: MGI:5486345
• Gene: Rr27 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm2.1Pes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195982
• Parent Cell Line: 2A (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: The 15 nuclear hormone receptor hexad recognition sites in the ICR upstream of H19 were mutagenized to abolish protein binding. Cre-mediated recombination removes the loxP site flanked neomycin resistance gene cassette that was inserted. (J:195982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 6 strains or lines available

References

• Original: J:195982 Szabo PE, et al., Mutagenesis in mice of nuclear hormone receptor binding sites in the Igf2/H19 imprinting control region. Cytogenet Genome Res. 2006;113(1-4):238-46
• All: 1 reference(s)