Myo7a^dmbo2
Chemically induced Allele Detail

Summary

• Symbol: Myo7a^dmbo2
• Name: myosin VIIA; dumbo2
• MGI ID: MGI:5487403
• Synonyms: Myo7a^F947I
• Gene: Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Myo7a^dmbo2 page

Cochlear morphology in Myo7a^ewaso/Myo7a^ewaso and Myo7a^dmbo2/Myo7a^dmbo2 mice

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU mutagenesis induced a T to A point mutation that results in the amino acid substitution of isoleucine for phenylalanine at position 487 (F947I). Immunohistochemistry reveals a reduction of protein expression in sensory epithelium. (J:195666) Inheritance: Recessive

Schematic diagram showing the location of the Myo7a^ewaso and Myo7a^dmbo2 mutations

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo7a Mutation: 118 strains or lines available

References

• Original: J:195666 Miller KA, et al., Inner ear morphology is perturbed in two novel mouse models of recessive deafness. PLoS One. 2012;7(12):e51284
• All: 1 reference(s)