Tmsb4x^tm1Prri
Targeted Allele Detail

Summary

• Symbol: Tmsb4x^tm1Prri
• Name: thymosin, beta 4, X chromosome; targeted mutation 1, Paul Riley
• MGI ID: MGI:5487444
• Synonyms: Tmsb4x^tm1Tnr
• Gene: Tmsb4x Location: ChrX:165990089-165992311 bp, - strand Genetic Position: ChrX, 78.28 cM
• Alliance: Tmsb4x^tm1Prri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 2. Immunohistochemistry confirmed the absence of protein expression in E10.5 embryos and E14.5 hearts. (J:195902)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tmsb4x Mutation: 12 strains or lines available

References

• Original: J:195902 Rossdeutsch A, et al., Essential role for thymosin beta4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res. 2012 Aug 3;111(4):e89-102
• All: 5 reference(s)