Hprt1^{tm1(H1-RNAi:Tmsb4x)Prri}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(H1-RNAi:Tmsb4x)Prri}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Paul Riley
• MGI ID: MGI:5487445
• Synonyms: Tbeta4 shRNA
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(H1-RNAi:Tmsb4x)Prri} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Hprt1^{tm1(H1-RNAi:Tmsb4x)Prri} involves 1 genes/genome features (Tmsb4x) View all
• Mutation details: The expression cassette containing the H1 RNA polymerase III promoter, floxed STOP and the short hairpin RNA targeting Tmsb4x was inserted into the locus. (J:195902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:195902 Rossdeutsch A, et al., Essential role for thymosin beta4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res. 2012 Aug 3;111(4):e89-102
• All: 3 reference(s)