Pex11a^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Pex11a^tm1Itl
• Name: peroxisomal biogenesis factor 11 alpha; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5487452
• Gene: Pex11a Location: Chr7:79385705-79392879 bp, - strand Genetic Position: Chr7, 45.12 cM, cytoband D2
• Alliance: Pex11a^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195940
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression in the liver. (J:195940)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex11a Mutation: 8 strains or lines available

References

• Original: J:195940 Weng H, et al., Pex11alpha deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E187-96
• All: 1 reference(s)