Sqstm1^tm2.1Jmos
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm2.1Jmos
• Name: sequestosome 1; targeted mutation 2.1, Jorge Moscat
• MGI ID: MGI:5487454
• Synonyms: p62^fl, p62^loxp
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm2.1Jmos page

Enhanced lipid deposition with increased lipid droplet sizes of brown adipose tissue in Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Tg(Fabp4-cre)1Rev/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194291
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed (J:194291)

Generation of the Sqstm1^tm2.1Jmos allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 35 strains or lines available

References

• Original: J:194291 Muller TD, et al., p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest. 2013 Jan 2;123(1):469-78
• All: 13 reference(s)