Abhd12^tm1Crv
Targeted Allele Detail

Summary

• Symbol: Abhd12^tm1Crv
• Name: abhydrolase domain containing 12; targeted mutation 1, Benjamin F Cravatt
• MGI ID: MGI:5487621
• Gene: Abhd12 Location: Chr2:150674413-150746661 bp, - strand Genetic Position: Chr2, 74.74 cM
• Alliance: Abhd12^tm1Crv page

Age-dependent increase in microglial activation in Abhd12^tm1Crv/Abhd12^tm1Crv brain

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193716
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 8, 9 and 10. Western blot analysis confirmed the absence of protein expression in brain membrane proteosomes. (J:193716)

Generation of the Abhd12^tm1Crv allele

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd12 Mutation: 32 strains or lines available

References

• Original: J:193716 Blankman JL, et al., ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1500-5
• All: 8 reference(s)