Ubr4^tm1.1Ytkw
Targeted Allele Detail

Summary

• Symbol: Ubr4^tm1.1Ytkw
• Name: ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yong Tae Kwon
• MGI ID: MGI:5487648
• Gene: Ubr4 Location: Chr4:139107970-139216844 bp, + strand Genetic Position: Chr4, 70.66 cM
• Alliance: Ubr4^tm1.1Ytkw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196073
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 36 - 42 were replaced with an IRES-tau-LacZ cassette and a floxed tACE-Cre-Neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:196073)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr4 Mutation: 247 strains or lines available

References

• Original: J:196073 Tasaki T, et al., UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5
• All: 3 reference(s)