Panx1^tm1.1Vshe
Targeted Allele Detail

Summary

• Symbol: Panx1^tm1.1Vshe
• Name: pannexin 1; targeted mutation 1.1, Valery I Shestopalov
• MGI ID: MGI:5487761
• Gene: Panx1 Location: Chr9:14917081-14956774 bp, - strand Genetic Position: Chr9, 4.52 cM
• Alliance: Panx1^tm1.1Vshe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196355
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette and exons 3 and 4. Western blot analysis confirmed the absence of protein expression in the brain and retina. (J:196355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Panx1 Mutation: 38 strains or lines available

References

• Original: J:196355 Dvoriantchikova G, et al., Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One. 2012;7(2):e31991
• All: 17 reference(s)