Tdg^tm1Psch
Targeted Allele Detail

Summary

• Symbol: Tdg^tm1Psch
• Name: thymine DNA glycosylase; targeted mutation 1, Primo Schar
• MGI ID: MGI:5487834
• Gene: Tdg Location: Chr10:82465662-82486633 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tdg^tm1Psch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196431
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 6 and 7. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:196431)

Generation of the Tdg^tm1Psch allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdg Mutation: 23 strains or lines available

References

• Original: J:196431 Kunz C, et al., Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biol. 2009 Apr 28;7(4):e91
• All: 3 reference(s)