Tg(Tlr7)6Boll
Transgene Detail

Summary

• Symbol: Tg(Tlr7)6Boll
• Name: transgene insertion 6, Silvia Bolland
• MGI ID: MGI:5488498
• Synonyms: TLR7.Tg.6
• Transgene: Tg(Tlr7)6Boll Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Tlr7)6Boll page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tlr7)6Boll expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tlr7 (MGI:2176882)

• Mutation details: The RP23-139P21 BAC construct that contains the Tlr7, Tlr8, and Tmsb4x genes, was replaced the first 83 kb with a neomycin cassette so that Tlr7 is be the only gene expressed. Six founder lines were produced with varying insert numbers and expression levels 4 to 16 fold greater than controls. This line has a 4- to 8-fold increase in expression. (J:127600)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127600 Deane JA, et al., Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity. 2007 Nov;27(5):801-10
• All: 3 reference(s)