Cxcl12^tm1.2Sjm
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.2Sjm
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1.2, Sean J Morrison
• MGI ID: MGI:5488499
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.2Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194748
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted 5' of exon 2 and an Frt-Neo-Frt-loxP cassette was placed 3' of the same exon. The selection cassette was subsequently removed by crossing with mice expressing flp recombinase. Germline cre expression excised exon 2 and created a frame shift mutation. (J:194748)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 25 strains or lines available

References

• Original: J:194748 Ding L, et al., Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013 Mar 14;495(7440):231-5
• All: 2 reference(s)