Tg(CAG-Rrm2)#Rsw
Transgene Detail

Summary

• Symbol: Tg(CAG-Rrm2)#Rsw
• Name: transgene insertion, Robert S Weiss
• MGI ID: MGI:5488606
• Synonyms: Rrm2^Tg
• Transgene: Tg(CAG-Rrm2)#Rsw Location: unknown
• Alliance: Tg(CAG-Rrm2)#Rsw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Rrm2)#Rsw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rrm2 (MGI:98181)

• Mutation details: Mouse cDNA encoding Rrm2 is expressed under the control of chicken beta-actin promoter and cytomegalovirus enhancer regulatory sequences ("CAG" promoter). Two Rrm2 transgene-positive founders were generated and subsequently maintained on a pure FVB/N strain background, but these lines were not distinguished in experimental descriptions. (J:133963)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Rrm1^tm1.1Ofc/Rrm1^tm1.1Ofc Tg(CAG-Rrm2)#Rsw/0	involves: 129 * C57BL/6 * FVB/N * SJL
cx2	Rrm1^tm1.1Ofc/Rrm1^tm1.1Ofc Tg(CAG-Rrm2)#Rsw/Tg(CAG-Rrm2)#Rsw	involves: 129 * C57BL/6 * FVB/N * SJL

Phenotypes:

Affected Systems	cx1	cx2
show or hide all annotated terms
mortality/aging	√	√
embryonic lethality before implantation, complete penetrance	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133963 Xu X, et al., Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 2008 Apr 15;68(8):2652-60
• All: 5 reference(s)