Krt7^tm1Whim
Targeted Allele Detail

Summary

• Symbol: Krt7^tm1Whim
• Name: keratin 7; targeted mutation 1, William Henry Irwin McLean
• MGI ID: MGI:5488745
• Gene: Krt7 Location: Chr15:101310284-101325687 bp, + strand Genetic Position: Chr15, 56.88 cM
• Alliance: Krt7^tm1Whim page

Hyperproliferation of the bladder urothelium in Krt7^tm1Whim/Krt7^tm1Whim mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196575
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced by a neomycin selection cassette. Western blot analysis confirmed the absence of protein expression in the bladder, lung and colon. (J:196575)

Generation of the Krt7^tm1Whim allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt7 Mutation: 30 strains or lines available

References

• Original: J:196575 Sandilands A, et al., Generation and Characterisation of Keratin 7 (K7) Knockout Mice. PLoS One. 2013;8(5):e64404
• All: 1 reference(s)