Ret^tm6.2Vpa
Targeted Allele Detail

Summary

• Symbol: Ret^tm6.2Vpa
• Name: ret proto-oncogene; targeted mutation 6.2, Vassilis Pachnis
• MGI ID: MGI:5489748
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm6.2Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195828
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and exon 1. (J:195828)

Generation of the Ret^tm6.1Vpa and Ret^tm6.2Vpa alleles

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ret^tm6.1Vpa/Ret^tm6.2Vpa Tg(CD2-icre)4Kio/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
hematopoietic system	N
hematopoietic system phenotype	N
immune system	N
immune system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:195828 Almeida AR, et al., RET/GFRalpha signals are dispensable for thymic T cell development in vivo. PLoS One. 2012;7(12):e52949
• All: 1 reference(s)