Has2^tm1.1Chg
Targeted Allele Detail

Summary

• Symbol: Has2^tm1.1Chg
• Name: hyaluronan synthase 2; targeted mutation 1.1, Chin Chiang
• MGI ID: MGI:5489753
• Synonyms: Has2^flox
• Gene: Has2 Location: Chr15:56529023-56557935 bp, - strand Genetic Position: Chr15, 23.31 cM
• Alliance: Has2^tm1.1Chg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194283
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:194283)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Has2 Mutation: 35 strains or lines available

References

• Original: J:194283 Liu J, et al., Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning. Dev Biol. 2013 Mar 15;375(2):160-71
• All: 2 reference(s)