Or8a1^tm38Mom
Targeted Allele Detail

Summary

• Symbol: Or8a1^tm38Mom
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 38, Peter Mombaerts
• MGI ID: MGI:5489815
• Synonyms: M71-RDY, M71(RDY)-lacZ
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^tm38Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233447
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutation: Nucleotide substitutions
• Mutation details: Two amino acid substitutions, D121R and R122D, were made in this targeted mutation to interfere with G protein coupling via the highly conserved DRY motif, and an IRES-taulacZ reporter sequence was inserted downstream for bicistronic expression. (J:233447)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
• All: 1 reference(s)