Snx17b2b1625.1Clo
Chemically induced Allele Detail
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Symbol: |
Snx17b2b1625.1Clo |
Name: |
sorting nexin 17; Bench to Bassinet Program (B2B/CVDC), mutation 1625, subline 1 Cecilia Lo |
MGI ID: |
MGI:5489924 |
Gene: |
Snx17 Location: Chr5:31350634-31356244 bp, + strand Genetic Position: Chr5, 17.26 cM
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Alliance: |
Snx17b2b1625.1Clo page
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Mutant 1625-002-NB displays malpositioning of the great arteries which was confirmed to be overriding aorta by EFIC imaging
Show the 14 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6J
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Project Collection: |
B2B/CvDC
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1625Clo. The molecular lesion is an A to G substituation at coding nucleotide 431 in exon 5 of the cDNA (c.431A>G, NM_153680). This changes the glutamic acid residue to glycine at position 144 of the encoded protein (p.E144G).
(J:175213)
Additional
incidental mutations
were detected in sequencing for the causative mutation,
Snx17b2b1625.1Clo, and may be present in stocks carrying this mutation.
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View phenotypes and curated references for all genotypes (concatenated display).
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This mutation is present in a subline of b2b1625Clo.
Summative Diagnosis:
Cardiac phenotype: Double outlet right ventricle (DORV)/overriding aorta (Ao), atrioventricular septal defect (AVSD)
Noncardiac phenotype: Anopthalmia, duplex kidneys
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