Cbx4^tm1.2Gxu
Targeted Allele Detail

Summary

• Symbol: Cbx4^tm1.2Gxu
• Name: chromobox 4; targeted mutation 1.2, Guo-Liang Xu
• MGI ID: MGI:5489932
• Gene: Cbx4 Location: Chr11:118968399-118977047 bp, - strand Genetic Position: Chr11, 83.34 cM
• Alliance: Cbx4^tm1.2Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194053
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 1 and 2. (J:194053)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbx4 Mutation: 16 strains or lines available

References

• Original: J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
• All: 2 reference(s)