Adgrf5^tm1.1Bstc
Targeted Allele Detail

Summary

• Symbol: Adgrf5^tm1.1Bstc
• Name: adhesion G protein-coupled receptor F5; targeted mutation 1.1, Brad St Croix
• MGI ID: MGI:5490501
• Synonyms: Gpr116^flox
• Gene: Adgrf5 Location: Chr17:43671342-43770448 bp, + strand Genetic Position: Chr17, 19.73 cM
• Alliance: Adgrf5^tm1.1Bstc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196943
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2 and a frt- and loxP-flanked neomycin resistance (neo) cassette downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:196943)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgrf5 Mutation: 74 strains or lines available

References

• Original: J:196943 Yang MY, et al., Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116. Cell Rep. 2013 May 30;3(5):1457-64
• All: 4 reference(s)