Siglece^tm1Croc
Targeted Allele Detail

Summary

• Symbol: Siglece^tm1Croc
• Name: sialic acid binding Ig-like lectin E; targeted mutation 1, Paul Crocker
• MGI ID: MGI:5490544
• Gene: Siglece Location: Chr7:43300494-43309585 bp, - strand Genetic Position: Chr7, 28.25 cM, cytoband B2
• Alliance: Siglece^tm1Croc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195429
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 and 2. Western blot analysis confirmed the absence of protein expression in bone marrow neutrophils and bone marrow derived macrophages. (J:195429)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Siglece Mutation: 32 strains or lines available

References

• Original: J:195429 McMillan SJ, et al., Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling. Blood. 2013 Mar 14;121(11):2084-94
• All: 4 reference(s)