Nrl^tm1.1Jcco
Targeted Allele Detail

Summary

• Symbol: Nrl^tm1.1Jcco
• Name: neural retina leucine zipper gene; targeted mutation 1.1, Joseph C Corbo
• MGI ID: MGI:5490568
• Synonyms: Nrl^CKO
• Gene: Nrl Location: Chr14:55756973-55762438 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Nrl^tm1.1Jcco page

Adult rods are reprogrammed into cone-like cells in Nrl^tm1.1Jcco/Nrl^tm1.1Jcco and Nrl^tm1Asw/Nrl^tm1Asw retinas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193697
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the floxed exon 3. In situ hybridization confirmed lack of transcript expression in the retina. (J:193697)

Generation of the Nrl^tm1Jcco and Nrl^tm1.1Jcco alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrl Mutation: 18 strains or lines available

References

• Original: J:193697 Montana CL, et al., Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1732-7
• All: 1 reference(s)