Stra6^tm1Nbg
Targeted Allele Detail

Summary

• Symbol: Stra6^tm1Nbg
• Name: stimulated by retinoic acid gene 6; targeted mutation 1, Norbert B Ghyselinck
• MGI ID: MGI:5490784
• Synonyms: Stra6^L-, Stra6^tm2.2Nbg
• Gene: Stra6 Location: Chr9:57971071-58061279 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband C
• Alliance: Stra6^tm1Nbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196841
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 5 through 7. Western blot analysis confirmed the absence of protein expression in E9.5 embryos and the retinal pigment epithelium. This allele was generated from Stra6^tm2.1. (J:196841, J:203449)

Generation of the Stra6^tm2.1Nbg and Stra6^tm1Nbg alleles

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stra6 Mutation: 50 strains or lines available

References

• Original: J:196841 Ruiz A, et al., Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012;53(6):3027-39
• All: 4 reference(s)