Asic1^tm1.1Ccli
Targeted Allele Detail

Summary

• Symbol: Asic1^tm1.1Ccli
• Name: acid-sensing ion channel 1; targeted mutation 1.1, Cheng-Chang Lien
• MGI ID: MGI:5490899
• Synonyms: ASIC1a^flx, Asic1^tm1Lien
• Gene: Asic1 Location: Chr15:99568249-99599011 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Asic1^tm1.1Ccli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:193892)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic1 Mutation: 42 strains or lines available

References

• Original: J:193892 Wu PY, et al., Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J Neurosci. 2013 Jan 30;33(5):1828-32
• All: 8 reference(s)