Rgs12^tm1.1Syy
Targeted Allele Detail

Summary

• Symbol: Rgs12^tm1.1Syy
• Name: regulator of G-protein signaling 12; targeted mutation 1.1, Shuying Yang
• MGI ID: MGI:5490960
• Synonyms: Rgs12^flox
• Gene: Rgs12 Location: Chr5:35106789-35196988 bp, + strand Genetic Position: Chr5, 17.96 cM
• Alliance: Rgs12^tm1.1Syy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:194057)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs12 Mutation: 60 strains or lines available

References

• Original: J:194057 Yang S, et al., Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 2013 Mar;51(3):201-9
• All: 4 reference(s)