Hoxb2^tm3.1Fmr
Targeted Allele Detail

Summary

• Symbol: Hoxb2^tm3.1Fmr
• Name: homeobox B2; targeted mutation 3.1, Filippo M Rijli
• MGI ID: MGI:5490993
• Synonyms: Hoxb2^flox
• Gene: Hoxb2 Location: Chr11:96242458-96244846 bp, + strand Genetic Position: Chr11, 59.85 cM
• Alliance: Hoxb2^tm3.1Fmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197162
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette was inserted into the Hoxb2 intron, downstream of the translation start codon. Frt sites flanked the cassette with a loxP site following the 3' Frt site. Another loxP site was inserted into the Hoxb2 3' UTR downstream of the stop codon. Animals were crossed to Flpe deleter mice, excising the PGK-neo. (J:197162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb2 Mutation: 12 strains or lines available

References

• Original: J:197162 Di Bonito M, et al., Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem. PLoS Genet. 2013;9(2):e1003249
• All: 1 reference(s)