Tg(Prnp*P101L)2862Sbp
Transgene Detail

Summary

• Symbol: Tg(Prnp*P101L)2862Sbp
• Name: transgene insertion 2862, Stanley B Prusiner
• MGI ID: MGI:5491026
• Synonyms: Tg(MoPrP-P101L)2862
• Transgene: Tg(Prnp*P101L)2862Sbp Location: unknown
• Alliance: Tg(Prnp*P101L)2862Sbp page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*P101L)2862Sbp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)	Transgene codes for a protein with a proline to leucine mutation.

• Mutation details: This transgene construct consists of the mouse Prnp containing a substitution of a leucine for proline codon at residue 101, corresponding to the Gerstmann-Straussler-Scheinker disease mutation at codon 102 of the human PRNP gene, in the cosSHa.Tet vector. This line overexpresses the transgene about 32-fold. Three lines were generated; 2247, 2866, and 2862 (J:136434)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:136434 Telling GC, et al., Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev. 1996 Jul 15;10(14):1736-50
• All: 1 reference(s)