Tg(MECP2*R270X/GFP)AHzo
Transgene Detail

Summary

• Symbol: Tg(MECP2*R270X/GFP)AHzo
• Name: transgene insertion A, Huda Y Zoghbi
• MGI ID: MGI:5491036
• Synonyms: MeCP2-R270X, R270X^Tg
• Transgene: Tg(MECP2*R270X/GFP)AHzo Location: unknown
• Alliance: Tg(MECP2*R270X/GFP)AHzo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(MECP2*R270X/GFP)AHzo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MECP2 (4204)

  Mecp2

  (MGI:99918)

• Mutation details: A human PAC containing only the endogenous MECP2 locus was modified to bear an R270X mutation. Founder line A is selected as a representative line. (J:194039)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:194039 Baker SA, et al., An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders. Cell. 2013 Feb 28;152(5):984-96
• All: 2 reference(s)