Map3k8^tm1Sley
Targeted Allele Detail

Summary

• Symbol: Map3k8^tm1Sley
• Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Steven C Ley
• MGI ID: MGI:5491226
• Synonyms: Map3k8^D270A
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^tm1Sley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitution(s) results in the amino acid substitution of alanine for aspartic acid at position 270 (D270A). (J:196528)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:196528 Yang HT, et al., Coordinate regulation of TPL-2 and NF-kappaB signaling in macrophages by NF-kappaB1 p105. Mol Cell Biol. 2012 Sep;32(17):3438-51
• All: 5 reference(s)