L1cam^tm2.1Vlem
Targeted Allele Detail

Summary

• Symbol: L1cam^tm2.1Vlem
• Name: L1 cell adhesion molecule; targeted mutation 2.1, Vance Lemmon
• MGI ID: MGI:5491824
• Synonyms: L1^Y1176A
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm2.1Vlem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197240
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Nucleotide substitution(s) result(s) in the amino acid substitution of alanine for tyrosine at position 1176 (Y1176A). This allele lacks the AP-2 binding site and a site involved in ERM interactions. Cre-mediated recombination removed the floxed neo cassette inserted into intron 26. Western blot analysis confirmed expression of the protein in the brain. (J:197240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:197240 Nakamura Y, et al., Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development. J Comp Neurol. 2010 Apr 1;518(7):1113-32
• All: 2 reference(s)