Sppl2a^tm1Basc
Targeted Allele Detail

Summary

• Symbol: Sppl2a^tm1Basc
• Name: signal peptide peptidase like 2A; targeted mutation 1, Bernd Schroder
• MGI ID: MGI:5491887
• Gene: Sppl2a Location: Chr2:126732311-126775155 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband F3
• Alliance: Sppl2a^tm1Basc page

Atrophic Peyer's patches in Sppl2a^tm1Basc/Sppl2a^tm1Basc mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194664
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A neomycin resistance cassette was inserted into exon 2. Western confirmed the lack of protein expression in splenocytes. (J:194664)

Generation of the Sppl2a^tm1Basc allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sppl2a Mutation: 47 strains or lines available

References

• Original: J:194664 Schneppenheim J, et al., The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J Exp Med. 2013 Jan 14;210(1):41-58
• All: 7 reference(s)