Ctsk^tm1.1Rbar
Targeted Allele Detail

Summary

• Symbol: Ctsk^tm1.1Rbar
• Name: cathepsin K; targeted mutation 1.1, Roland Baron
• MGI ID: MGI:5492037
• Synonyms: Ctsk^fl
• Gene: Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctsk^tm1.1Rbar page

Increase in cancellous bone mass in Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194492
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette and left exon 5 floxed. (J:194492)

Generation of the Ctsk^tm1.1Rbar allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsk Mutation: 31 strains or lines available

References

• Original: J:194492 Lotinun S, et al., Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest. 2013 Feb;123(2):666-81
• All: 2 reference(s)