Gt(ROSA)26Sor^{tm1(Cdkn1c)Jfpa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Cdkn1c)Jfpa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, James Padbury
• MGI ID: MGI:5492378
• Synonyms: Gt(ROSA)26Sor^{tm1(xstpx-Cdkn1c)Jfpa}, R26loxpTA-p57, R26loxpTA-p57^k, R26loxpTA-p57^Kip2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Cdkn1c)Jfpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197451
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Cdkn1c)Jfpa} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cdkn1c (MGI:104564)

• Mutation details: A 1.4 kb cDNA containing the complete open reading frame of the mouse gene was placed under the control of a loxP-flanked transcriptional termination sequence. This construct was inserted between exons 1 and 2. (J:197451)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:197451 Haley SA, et al., Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart. BMC Physiol. 2008;8:4
• All: 2 reference(s)