Tg(Prnp-CCS)17Jlel
Transgene Detail

Summary

• Symbol: Tg(Prnp-CCS)17Jlel
• Name: transgene insertion 17, Jeffrey L Elliott
• MGI ID: MGI:5492387
• Transgene: Tg(Prnp-CCS)17Jlel Location: unknown
• Alliance: Tg(Prnp-CCS)17Jlel page

Transgene origin

• Strain of Origin: B6SJLF1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-CCS)17Jlel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCS (9973)

  Ccs	(MGI:1333783)

• Mutation details: Human wild type copper chaperone for SOD1 cDNA was cloned into a mouse prion protein promoter construct. Line 17 showed the highest levels of expression in the spinal cord. (J:120361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:120361 Son M, et al., Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6072-7
• All: 2 reference(s)