Rbbp8^tm2Thl
Targeted Allele Detail

Summary

• Symbol: Rbbp8^tm2Thl
• Name: retinoblastoma binding protein 8, endonuclease; targeted mutation 2, Thomas Ludwig
• MGI ID: MGI:5494423
• Synonyms: Ctip^S326A-neo
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^tm2Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 11 was replaced with a modified exon 11 in which nucleotide substitutions (TCT to GCA) result in the amino acid substitution of serine with alanine at position 326 (p.S326A). Additional nucleotide substitutions also introduce an Afel restriction site into the exon. (J:197743)

Generation of the Rbbp8^tm2Thl and Rbbp8^tm2.1Thl alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

References

• Original: J:197743 Reczek CR, et al., The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression. J Cell Biol. 2013 May 27;201(5):693-707
• All: 1 reference(s)